Vicore startar klinisk blodflödesstudie med C21

2022-03-18

· Mätning av blodflöde i underarm ”forearm blood flow” är en teknik för att mäta kärlvidgning och blodflöde i människa
· Om tekniken är framgångsrik, kan det leda till en snabbare och mer precis klinisk utveckling av nya ATRAG molekyler
· Studien är godkänd av Läkemedelsverket och planeras att starta under andra kvartalet 2022

Göteborg, 18 mars, 2022 – Vicore Pharma Holding AB (publ) (“Vicore”), ett läkemedelsbolag i klinisk fas som utvecklar angiotensin II typ 2-receptor agonister (ATRAGs) meddelar idag att man inleder en klinisk studie med C21* för att utvärdera blodflödesförändringar i underarmen på friska frivilliga personer.  

Som en del i utvecklingen av nya ATRAGs för olika sjukdomar, utvecklar Vicore en enkel metod för att tidigt etablera effektiv dos för angiotensin II typ 2-receptor (AT2R)-stimulering i människa. Om studien blir lyckad, kan en säkrare etablering av en effektiv dos öka sannolikheten för positiva resultat i fas 2/3 samt leda till effektivare och mindre resurskrävande utvecklingsprogram. “Med alla kliniska data som genererats med läkemedelskandidaten C21, så är det en stor fördel att ha en modell för att direkt kunna jämföra doser och effekter” säger Johan Raud, CSO i Vicore.

Om angiotensin II typ 2-receptor agonister (ATRAGs)

AT2R är en del av kroppens regenerering och reparationssystem och tros vara involverad i flera sjukdomar kopplade till hög ålder och cellernas åldrande inklusive idiopatisk lungfibros, kronisk njursjukdom, hjärtsvikt och kognitiva störningar. Att stimulera AT2R har visat sig vara effektivt i flera sjukdomsmodeller och den kliniska valideringen pågår vid akut och kronisk lungsjukdom. Stimulering av AT2R kan även vidga små artärer hos djur och människa för att lokalt öka blodflödet.

För ytterligare information, vänligen kontakta:

Carl-Johan Dalsgaard, VD, tel: 070 975 98 63, carl-johan.dalsgaard@vicorepharma.com  

Informationen lämnades för offentliggörande den 18 mars 2022 kl 08:00 CET.

*NCT05277922

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General

Vicore Pharma Holding AB (“Vicore”) shall only process personal data in accordance with applicable data protection law and high industry standards.

 

Personal data.

Vicore processes personal data provided to us;
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(ii) in connection with entering into or performing an agreement or business arrangement with you, or
(iii) by a third party allowed by law or your consent.

The personal data may consist of contact and identification details and other information relevant to the situation.

 

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Vicore process personal data for the purpose of communicating with you and to perform, manage and comply with agreements between us as well as rights and obligations which are allowed by law or applicable regulation.

 

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The legal grounds for processing personal data is either;
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(ii) a legitimate interest allowed under law.

 

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Vicore shall use adequate technical and organisational security measures to protect the personal data from loss and to safeguard against access from unauthorised persons.

Transfers of personal data may only occur;
(i) to third parties who perform services on Vicore behalf and who may only process personal data in accordance with our instructions, and may not use personal data for their own purposes; and
(ii) outside the EU/EEA only in accordance with applicable data protection laws and subject to the EU Commission’s standard contractual clauses, and
(iii) as otherwise permitted by law or your consent.

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Reports and complaints can also be directed to Datainspektionen who is the supervisory authority for our processing of personal data.