Frontiers in Physiology publish data with C21 on pulmonary fibrosis
A recently accepted manuscript entitled “The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury” (Rathinasabapathy et al., Front Physiol 2018, 9:180. doi: 10.3389/fphys.2018.00180) reports about the anti-fibrotic effect of Vicore Pharma’s lead compound, C21, in one of the standard preclinical models for idiopathic pulmonary fibrosis (IPF), which is pulmonary fibrosis in rodents induced by a single intra-tracheal installation of bleomycin.
C21 was applied to the animals according to two protocols, which both lasted 14 days: in one of the protocols, treatment was started on the day of bleomycin installation to test a preventive effect of C21 on the development of pulmonary fibrosis, in the other protocol, treatment with C21 was started on day 3 after bleomycin installation to test a therapeutic effect of C21 in animals with already established fibrosis. In both cases, treatment with C21 almost completely prevented the further development of fibrosis. Some of the markers such as collagens 1 and 3, TIMP or CTGF were reduced by C21 treatment down to levels in non-fibrotic lungs.
Of note, in addition to the anti-fibrotic effect, C21 treatment also attenuated pulmonary hypertension and vascular remodeling.
Thus, this study confirmed the therapeutic effect of C21 in pulmonary fibrosis and pulmonary hypertension as observed in a model of monocrotaline-induced pulmonary fibrosis in rats (Bruce et al., Br J Pharmacol 2015, 172: 2219–2231).
“The prevention and – in the previous monocrotaline study – even reversal of pulmonary fibrosis in combination with a significant therapeutic effect on pulmonary hypertension gives hope that C21 will in the future not only improve the respiratory function in patients with IPF, but also help to treat the deathly complication of pulmonary hypertension” says Prof. Michael Katovich, senior author of both studies.
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